Demerits Of Wet Granulation

Despite the many advantages of wet granulation, it also has limitations. Here are some of them:

1. The Process is Complex Without Machines

Some pharmaceutical companies opt for dry granulation and other methods because wet granulation can be complex. The technique is not easy, especially in the absence of the right equipment. So, whoever is planning to take advantage of the benefits of this procedure must be ready to invest in machines. With the aid of top-class wet granulators, the process is seamless. Without them, it is best to consider other approaches.

2. It is More Expensive

The cost-effective attraction of dry granulation is one of the reasons it appeals to many companies. Wet granulation requires more capital, and that is the reason startups and small companies in the industry avoid it. Yet, any pharmaceutical firm that wants to move on to the next level has to invest in such machines. They are always worth the extra cost.

3. It Requires More Effort And Energy Consumption

Pharmaceutical companies without a steady supply of energy will struggle with this technique. It requires a stable supply of electricity to power the machines for carrying out this process. So, it is advisable that a company is willing to invest in renewable sources of energy before considering this method. This is particularly important to companies that do not have access to a stable electricity supply. Yet, the fact that most such firms operate in cities will help solve this challenge.

4. Not Suitable For Moisture Control

When dealing with moisture-sensitive materials, wet granulation is not the best approach. Yet, the lack of plenty of such substances in the pharmaceutical process ensures that this is not a significant challenge.