Superiority of Wet Granulation

In the wet granulation process, excipients are the extra materials in a drug apart from the active ingredient. It includes additives for colors and texture. Some help bind the tablet's particles together, while others preserve them.

Wet granulation does not need special excipients, while dry granulation usually needs such inputs. It is necessary to compensate for its deficiency. Thus, the chances are high that the drugs produced through this procedure will be more potent.

One of the major reasons wet granulation is popular is its content uniformity provision. Professional drug-makers do not want to make medication that appears substandard. So, they place a high value on the uniformity of their tablets. Wet granulation makes this process easier, especially when dealing with soluble low-dose medication. Wet granulation often struggles to achieve homogeneity with such drugs.

Drugs with poor dissolution rates are nightmares to drug makers. They take time, and manufacturers have no choice but to wait until the process ends. But wet granulation helps to overcome this challenge by speeding up the process. Increasing these drugs' dissolution speed makes the formulation and production procedure faster.

While producing, handling, transporting, and storing drugs, there is a chance of segregation of components. This occurrence is possible, especially when dealing with a uniform powder mix.

But, wet granulation reduces the chances of this event taking place. Thus, it limits variability in the form of inter-batch and intra-batch differences. This advantage increases the professionalism of pharmaceutical companies, enhancing their reputation in the industry.