Introduction of fluid bed granulation

Fluid bed granulation is converting fine size solid particles into large particles by continuous mixing in presence of granulating fluid. The process of granulation is very vast and multistep process have many disadvantages and such drawbacks overcome by the novel technique i.e, fluidized bed granulation and drying in fluidized bed processor.

Fluidized bed granulation [ FBG] is one of most widely used technique in manufacturing of solid pharmaceutical products such as Granulation is also known as agglomeration. Fluidized Bed Granulator ( FBG), a highly economical and efficient one pot process, is a popular technique in the pharmaceutical.

Fluidized bed granulation is one of the many techniques i.e, drum granulation, pneumatic dry granulation, high shear granulation, and so on to produce agglomerates. Fluidized bed granulation technique is preferred over other techniques because it provides properly mixing, high heat and mass transfer rates, continues the bed more or less at uniform temperature.

In operation of fluidized bed granulator fine droplets of granulating solution are sprayed at the surface of fluidizing particles. when particles are wetted and collide to each other and formation of liquid bridges are converted into solid bridges. When they received adequate amount of heat form the fluidizing air, to drive off the solvent present. Hence the particles are adhere to each other to form agglomerates/ granules.

Fluidized bed granulation technique Recently, a method for preparation of solid dispersion using fluid bed granulation process. Solid dispersion using fluidized bed granulation process has been attracting attention as a manufacturing process because it overcomes so many drawbacks and problems arising in other multistep granulation and solid dispersion manufacturing processes.