Amoxicillin dry granulator machine for pharmacy

Amoxicillin dry granulator machine for pharmacy

$28000-120000 /Set/Sets

Payment Type:	T/T,L/C
Incoterm:	FOB,CFR,CIF,EXW,FCA
Min. Order:	1 Set/Sets
Transportation:	Ocean,Land,Air
Port:	Shanghai,Ningbo,Guangzhou

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Product Description

Product Attributes

Model No.: LG

Brand: Lead machinery

Place Of Origin: China

Old And New: New

Machine Type: Granulator

Video Factory Inspection: Provided

Mechanical Test Report: Provided

Core Component Warranty Period: 1 Year

Core Components: Plc, Gearbox, Motor

Warranty Period: 1 Year

Core Selling Point: Famous Brand Plc

Applicable Industry: Food &Amp; Beverage Factory, Energy &Amp; Mining, Other

Out-of-warranty Service: Field Maintenance And Repair Service, Video Technical Support, Online Support, Spare Parts

Where To Provide Local Services (in Which Countries Are There Overseas Service Outlets): Italy, Egypt, France, Indonesia, Japan

Showroom Location (in Which Countries Are There Sample Rooms Overseas): Italy, Egypt, Canada, Germany, Turkey, Viet Nam, Spain, Russia

Function: Dry granulation

Material Of Machine: SUS304/SUS316L

Material Of Roller: 3Cr13

Control System: Touch screen & PLC

Pressure Range: 0~25Mpa

Hydraulic Station: 0.75kW

Standard: GMP

Brand Of Control System: Siemens

Explosion-proof: Option

Customized: Support

Packaging & Delivery

Selling Units	:	Set/Sets
Package Type	:	Wooden case

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Product Description

Dry granulation also referred to as precompression or double compression is a size enlargement process designed to improve the flow and compression characteristics of powders that would otherwise be unsuitable for compression. The process involves compaction of powder particles into large pieces or compacts which are subsequently broken down into granules to produce granules that can be further processed into dosage forms.

Granules that made by dry granulator

Dry granulation is a systematic process. That means it occurs through a series of steps starting from the preparation of the material to the final blending of the granules. In each step, there are control measures used to ensure that the technique works as expected. Let us learn more about these steps.

Preparing the Material

One thing to keep in mind is that dry granulation is not only used in the pharmaceutical industry but also across multiple industries. It is just that pharma is among the pioneers of the technique. The process starts with the preparation of the dry powder that will be fed into the compressor or compaction unit. A lot can go on in this preparation.

To start with, the active ingredient in the powder is mixed with excipients — inert compounds that facilitate dry granulation.

After the active ingredients and the excipients are mixed, they are blended in special grinders to produce a homogeneous powder. This powder is then fed into the specific machine for the agglomeration to occur.

Feeding the Compaction Unit

Compaction is defined as the use of force to pack matter tightly. This is the step in the process that matters the most.

Dry granulation can be carried out using various techniques. The most widely used in pharma are slugging and roller compaction. The technique of the Lead dry granulator is roller compaction.

Roller compactors form long ribbons using two rollers that rotate in opposite directions. We will elaborate more about how this works in another section of the article.

Crushing and Milling Process

The actual granulation of the dry powder occurs in this step. Milling involves the breakdown of the slug and the long ribbons into small granules.

The size of the particles depends on the hole diameter of the milling sieve. In general:

If the granules will be used for pressing tablet or filling capsules, the size of granules is from 20 meshes to 80meshes.

If the granules will be used as instant granules (especially traditional Chinese medicine), the size can is from 8 meshes to 40 meshes.

Final Blending

At the milling step, most of the work is usually done. However, in some cases, a final blend is needed. This blend can involve the addition of other excipients in the granules. It is meant to improve the qualities of the granule compounds.