Chinese medicine double roll granulator machine dry granulation

Chinese medicine double roll granulator machine dry granulation

$28000-120000 /Set/Sets

Payment Type:	T/T,L/C
Incoterm:	FOB,CFR,CIF,EXW,FCA
Min. Order:	1 Set/Sets
Transportation:	Ocean,Land,Air
Port:	Shanghai,Ningbo,Guangzhou

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Product Description

Product Attributes

Model No.: LG

Brand: Lead machinery

Place Of Origin: China

Old And New: New

Machine Type: Granulator

Video Factory Inspection: Provided

Mechanical Test Report: Provided

Core Component Warranty Period: 1 Year

Core Components: Plc

Warranty Period: 1 Year

Core Selling Point: Famous Brand Plc

Applicable Industry: Food &Amp; Beverage Factory, Energy &Amp; Mining, Other

Out-of-warranty Service: Field Maintenance And Repair Service

Where To Provide Local Services (in Which Countries Are There Overseas Service Outlets): Italy, Germany, Australia, Malaysia, Japan, Russia, Spain

Showroom Location (in Which Countries Are There Sample Rooms Overseas): Italy, Malaysia, Australia, Turkey, Mexico, Russia, Spain

Function: Dry granulation

Material Of Machine: SUS304/SUS316L

Material Of Roller: 3Cr13

Control System: Touch screen & PLC

Pressure Range: 0~25Mpa

Hydraulic Station: 0.75kW

Standard: GMP

Brand Of Control System: Siemens

Explosion-proof: Option

Customized: Support

Packaging & Delivery

Selling Units	:	Set/Sets
Package Type	:	Wooden case
Picture Example	:

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ROLLER COMPACTOR

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Product Description

Description of Roller compactor dry granulation:

Dry granulation is one of the process steps in the pharmaceutical OSD manufacturing process, where raw ingredient powders are conditioned ready to be formed into tablets. It is a granulation method that takes the dry, primary ingredient powders and compresses these smaller particles together into larger granules, in order to lock-in ingredient ratios and ensures the right amount of excipient is included in every single tablet, as well as create the granule properties necessary for feeding the subsequent process steps.

These larger granules are created with Roller Compactor equipment that compresses the powders between two rotating rolls to create a compact/ribbon. This is then milled to create a powder at a target particle size and distribution, that will flow through to the tablet presses, where it is compacted into a tablet.

Flow chart of automatic dry granulation system

Advantages of roll compactor:

Improved powder flow as the ideal particle size distribution can be attained by adjusting the compaction and milling process. With a better granular mix, material flows more easily, which means that conveying and feeding into downstream processes become trouble-free, as caking and bridging are eliminated.

Enhanced compressibility at the tablet pressing stage can be achieved as the powders are conditioned correctly. The goal of Dry Granulation is to compress the powder but leave some compactibility so that the powder can still be formed in a tablet press.

Control particle hardness by adjusting the compression and milling stage parameters. Crush strength and disintegration can be important properties that are brought under control.

Control dissolution and dispersion rates by modifying hardness and particle size distribution.

Lower equipment CapEx costs. Dry Granulation does not use as many pieces of equipment as the Wet Granulation process. Dry Granulation only involves a Roll Compactor, mill & sieve and charging and discharging equipment. Whereas, Wet Granulation involves a high shear granulator, fluid bed drier, mills & sieves, charging and discharging equipment, which can run into multiple millions of dollars and takes up a lot of factory space, consumes significant amounts of energy, and requires significant manpower to operate the system.

Scalability is much more straightforward with Dry Granulation – results achieved on the lab or pilot scale models can be replicated at the production scale.