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Granulation synthesis and applications of granulation
Granulation synthesis According to the help of the liquid in the granulation process, the granulation methods in the world are divided into dry granulation method and wet granulation method. In a dry granulator, instead of added water or other solvent and a mixed suspension as binder and solution to provide that required bond strength and cohesion of the part
Granulation of pharmaceuticals and excipients
Granulation is a technique for enlarging the particle size by a granulation process. The process is one of the most important operations in the production of solid dosage forms such as tablets and capsules. The target drug and excipients are blended by granulation technology to provide an appropriate particle size distribution, which provides the basis for
Types of granulation processes
One of the first steps in the tablet manufacturing process is blending the active pharmaceutical ingredient (API) and the excipients (these are components other than the active substances) until a homogeneous mixture is achieved. Granulation helps with this, and it is done either in a free fall blender or in a high-shear mixer with strong shear forces if the API is low-dose.
Apart from the disadvantages that are observed with this technique, there are specific challenges that can be considered setbacks when you are considering dry granulation as a production technique for solid granules. Some of these setbacks include;
Disadvantages of the Dry Granulation Technique
Whereas dry granulation is an almost perfect technique for producing solid granules without using water, it has some flaws. Some of the common disadvantages of this technique involve the final product and not the process itself. The following are some of them;
As one of the most common granulation methods, dry granulation has several advantages. This is what makes it preferred to wet granulation. Some of these benefits include; Cost-effective Granulation Method
Characteristics of Granules Made by Roller Compactor Dry Granulation
The end products of dry granulation techniques are known as granules. These small or large solid dosages have some notable characteristics that define them. Here are some of these characteristics and features.
Types of Dry Granulation Techniques
When dry granulation was invented, some techniques were adopted immediately and became an industry standard. Roller compaction is one of these techniques. Pneumatic dry granulation was developed in a bid to improve the current roller compaction as a dry granulation technique. This method has technical improvements t
Dry granulation is a systematic process. That means it occurs through a series of steps starting from the preparation of the material to the final blending of the granules. In each step, there are control measures used to ensure that the technique works as expected. Let us learn more about these steps.
There are many definitions of dry granulation process. However, all of them revolve around one singular idea - producing granules from dry powder without adding any water. Dry granulation relies on compaction and compression techniques to pack the dry powder in a way that it will not crumble easily. This is quite challenging, but the machines used for dry granulation are effective.
Theory of fluid bed granulation
Fluid bed granulator is one of the most important granulating equipment in pharmaceutical industry, food industry and chemical industry.
The factors affecting the fluidized bed granulation process (Three)
The fluid bed granulation process is a robust process that requires precise and repeatable control of all critical process parameters. Effective and reliable process control tools are required to ensure the quality of the final product. The factors affecting the fluidized bed granulation process can be divided into three categories: formulation-related var
The factors affecting the fluidized bed granulation process (Two)
The factors affecting the fluidized bed granulation process can be divided into three categories: formulation-related variables, equipment-related variables and process-related variables. Equipment-dependent variables: Agglomeration and attrition due to random fluidization, need to control particles during granulation. This is a complex process because the prevailing fluidiz
The factors affecting the fluidized bed granulation process (One)
Ideally, the primary particles in the fluidized bed come into contact with the wetting agent droplets when they pass through the spray zone, and the wetting agent diffuses on the surface of the particles to wet the particles. At the same time, the particles collide with each other to form a liquid bridge, and then dry and solidify in the fluidized bed to form particles. The factors a
The Advantages Of Fluid Bed Granulation
During fluid bed granulation, high-velocity air is used to suspend powdered material within a fluid bed granulator. This specialized, multi-purpose piece of equipment is capable of mixing, granulating, and drying, obviating the requirement to use separate instrumentation for each stage of the process. Designed to introduce the air stream into the bed from below, the fluid bed granulator expands the bed upward to provide high heat and mass transfer surface area.
Fluid Bed Granulation Process Engineering
Fluid bed granulation involves four key mechanisms or rate processes that take place simultaneously and continuously inside the granulator. These are wetting (also referred to as nucleation), growth, consolidation, and breakage. The interaction between these different mechanisms determines the final size distribution of the granulated product, in addition to controlling important attributes such as density and porosity.
Introduction of fluid bed granulation
Fluid bed granulation is converting fine size solid particles into large particles by continuous mixing in presence of granulating fluid. The process of granulation is very vast and multistep process have many disadvantages and such drawbacks overcome by the novel technique i.e, fluidized bed granulation and drying in fluidized bed processor.
A fluidized bed dryer is a bed of solid particles with a stream of gas blowing upward through the particles at a rate high enough to set them in motion. Fluid-bed processing involves drying, cooling, agglomeration, granulation, and coating of particulate materials. As the gas (usually air) travels through the particle bed or product layer under controlled velocity conditions to create a fluidized state, it imparts a fluid-like behavior to the bed and provides rapid mixing of solids.
Despite the many advantages of wet granulation, it also has limitations. Here are some of them:
Wet granulation is the oldest and the most population technique in the pharmaceutical industry. Below are some of the advantages of wet granulation: 1. Masking of Tabulation Deficiencies Creating a tablet with a perfect shape can be challenging, especially when the material lacks such qualities.
Superiority of Wet Granulation
In the wet granulation process, excipients are the extra materials in a drug apart from the active ingredient. It includes additives for colors and texture. Some help bind the tablet's particles together, while others preserve them.
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